Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
More than 1 gout flare a year while taking gout pills may mean your medicine is not
doing enough to lower your
uric acid level and prevent the damaging effects of uncontrolled gout. KRYSTEXXA (kris-TEX-uh)
*Best results were seen after 6 to 12 months of treatment. Optimal treatment duration has not been established.
Jen’s gout symptoms were so severe, especially in her foot, that she described the feeling as “bone crushing.” She tried different oral medicines, but none could reduce the number of flares she was having. Then she learned about KRYSTEXXA.
No matter your insurance plan, we are committed to helping you pay the lowest amount for KRYSTEXXA. If your doctor prescribes KRYSTEXXA, a Patient Access Liaison (PAL) from Amgen By Your Side can show you possible ways to save.
Your doctor may prescribe KRYSTEXXA with a medication called methotrexate to reduce symptoms caused by uncontrolled gout. KRYSTEXXA lowers uric acid levels in the blood as soon as 24 hours after the first IV treatment. Patients saw best results at 6 to 12 months* on KRYSTEXXA along with methotrexate. Patients who used KRYSTEXXA along with methotrexate had fewer infusion reactions and more reductions in tophi, or gouty lumps.
*Optimal treatment duration has not been established.
71%of people on KRYSTEXXA along with methotrexate kept their uric acid levels below 6 mg/dL
39%of people on KRYSTEXXA alone kept their uric acid levels below 6 mg/dL
KRYSTEXXA is an infused medication and can cause infusion
reactions, which can be severe. In the clinical
study,
people who took KRYSTEXXA with methotrexate were less likely
to experience infusion reactions.
4%of people had infusion reactions while taking KRYSTEXXA with methotrexate
31%of people on KRYSTEXXA alone had infusion reactions
Your doctor will monitor you for reactions, and if needed, may make treatment adjustments.
KRYSTEXXA lowers your uric acid level enough in just 24 hours to soon start dissolving visible and nonvisible tophi.
54%of people receiving KRYSTEXXA with methotrexate dissolved at least 1 tophus, or gouty lump, by Month 12 of treatment compared with 31% of those who took KRYSTEXXA alone. These results were among patients who had tophi at baseline.
If you and your doctor decide methotrexate is not right for you, KRYSTEXXA is effective when taken alone.
Khash’s gout progressed so much that he had flares weekly. After his doctor recommended KRYSTEXXA, he reached out to Lindsey for support.
Another KRYSTEXXA patient, Brian, understood that starting a new IV treatment required a time commitment. Completing his KRYSTEXXA therapy gave him the freedom to get back to his everyday life.
Learn about Brian’s treatment journey and how his dedication to therapy helped him find relief from uncontrolled gout.
Managing uncontrolled gout can involve a lot of moving parts. Amgen By Your Side is a patient support program that offers one-on-one support from a Patient Access Liaison (PAL) who can:
Your PAL can answer occasional questions or partner with you through each step of your treatment. How much you interact is completely up to you.
Brian faced obstacles such as time and flexibility needed to complete treatment. Learn how Brian’s commitment to therapy helped him get back his everyday.
To help clear out harmful gout buildup and take back control of gout, it’s important to receive KRYSTEXXA every 2 weeks for 6 to 12 months or for as long as your doctor recommends.*
*Best results were seen after 6 to 12 months of treatment. Optimal treatment duration has not been established.
KRYSTEXXA works differently than oral gout medicines to quickly dissolve gout buildup.
Methotrexate can help KRYSTEXXA work better than it does without it.
With the help of his PAL, Logan managed to stay on track with his treatment for uncontrolled gout.
The key to controlling gout is to dissolve gout buildup. To do that you have to get your uric acid level low enough for long enough. KRYSTEXXA can be used to treat uncontrolled gout in patients who have kidney disease. Patients in clinical trials who had mild to moderate kidney disease had similar results to patients who did not have kidney disease. Patients with severe kidney disease were not included in the clinical trials. Explore the connection between kidney disease and gout.
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if you:
What should I tell my doctor before receiving treatment with KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical trials:
The most common side effects of
KRYSTEXXA
when given together with methotrexate were gout flares, joint pain,
coronavirus disease 2019
(COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA
were gout
flares, allergic reactions (including infusion reactions). See “What is the most
important information I
should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain,
coronavirus disease
2019 (COVID-19), and vomiting.
This is not a complete list of all possible side
effects. Call your
doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
