Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Uncontrolled gout can be painful and unpredictable and cause permanent damage to various parts of your body. Even after gout flares end, uric acid crystals caused by gout can stay in your body, settle in your joints, and damage your bones. Uric acid crystals can also build up in vital organs like the kidneys. If you have kidney disease and gout, it’s important to take control of gout.
See which joints can be damaged by uric acid crystal buildup and where uric acid crystal buildup has been observed.
FRONT
BACK
TAP TO ROTATE
Green areas represent uric acid crystal buildup. Artist’s rendition.
Narrator: Meet Charlotte. Mother of four and an avid gardener, who is living with gout. It’s been months since her last attack. So, for Charlotte, today is a good gout day. Or is it? Let’s take a look under the surface. The green represents
uric acid crystals, the cause of gout throughout her body. This means permanent bone and joint damage can happen in places unseen, even after flares end.
If you have more than 1 gout flare a year and your uric acid levels remain high, your inside gout may be different than your outside gout. Talk to your doctor today. And learn what you can do to get your gout back under control.
Uncontrolled gout is more than what meets the eye. See the damage uric acid crystals could be causing throughout your body.
Yes, uric acid crystal buildup has been observed on the heart. Uncontrolled gout can spread beyond the joints to almost anywhere throughout the body.
KRYSTEXXA has not been studied to remove urate deposition from the heart.
Though uncommon, small tophi or gouty lumps can form in your outer ear.
Yes, uric acid crystal buildup has been observed on the spine.
Yes, tophi, or gouty lumps, on your elbows can become large and painful.
Gout specialists are experts in diagnosing and treating uncontrolled gout.
A KRYSTEXXA Gout Nurse Advocate can tell you more and connect you with helpful support services.
Reach out Monday through Friday from 8:00 AM to 11:00 PM ET at 1-833-469-4688.
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if you:
What should I tell my doctor before receiving treatment with KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical trials:
The most common side effects of
KRYSTEXXA
when given together with methotrexate were gout flares, joint pain,
coronavirus disease 2019
(COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA
were gout
flares, allergic reactions (including infusion reactions). See “What is the most
important information I
should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain,
coronavirus disease
2019 (COVID-19), and vomiting.
This is not a complete list of all possible side
effects. Call your
doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.