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Working with the right doctor is key when treating uncontrolled gout

Uncontrolled gout is a serious disease and can build up in bones and joints and impact organs.* Seeing a specialist is important when gout is uncontrolled. Gout specialists are experts in diagnosing and treating uncontrolled gout.

*KRYSTEXXA has not been studied to repair damage to any of the body's organs.

Learn how different types of doctors address gout

Primary Care Physician

Video preview of Dr. Lyla Prather explaining

A Primary Care Physician (PCP) is typically the first contact for a person with an undiagnosed health concern. PCP Dr. Lyla Prather explains when it’s time to see a gout specialist.

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Hi, I’m Doctor Lyla Prather and I’m a primary care physician. I generally prescribe oral medications for patients with gout. If you’re taking oral medications to treat your gout and are still experiencing more than 1 flare or the presence of tophi in the last 12 months, your gout might be out of control, and it’s time for a referral to a gout specialist. Out-of-control gout can be painful, unpredictable, and cause permanent damage.

Talk to your primary care physician and ask them to refer you to a gout specialist. Gout specialists are experts in diagnosing and treating out-of-control gout. Find a gout specialist near you by entering your ZIP code in the search bar of the specialist finder.

Rheumatologist

Video preview of Dr. Orrin Troum explaining the role of rheumatologists for gout treatment

Rheumatologists diagnose, treat, and manage various inflammatory conditions affecting muscles, joints, and bones. Rheumatologist Dr. Orrin Troum explains the impact of untreated gout.

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Hi, I’m Doctor Orrin Troum, and I’m a board-certified rheumatologist. I specialize in diagnosing and treating inflammatory diseases that affect the bones and joints, like gout.

Gout is a form of arthritis that occurs when the body has a buildup of uric acid. Not treated effectively, uric acids from gout can actually stay in your body. If you're taking oral medications and are still experiencing more than 1 flare or the presence of tophi in the last 12 months, your gout may be out of control.

Find a gout specialist near you by entering your ZIP code in the specialist finder search bar.

Nephrologist

Video preview of Dr. Namrata Goel explaining the role of nephrologists for gout treatment

Nephrologists diagnose, treat, and manage acute and chronic kidney diseases. Dr. Namrata Goel explains the relationship between gout and kidney disease.

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Hi, I'm Doctor Namrata Goel, and I'm a board-certified nephrologist. I specialize in conditions that affect the kidneys. About 1 in 4 people with moderate to severe kidney disease also has gout. If you are experiencing more than 1 flare or the presence of tophi in the last 12 months, while on an oral gout medication, your gout may be out of control. This occurs because diseased kidneys can have a harder time removing uric acid. If gout is left untreated, uric acid can build up in your blood and form crystals that damage your kidneys.

Find a gout specialist near you by entering your ZIP code in the specialist finder search bar.

Podiatrist

Video preview of Dr. Scott Neville explaining the role of podiatrists for gout treatment

The first signs of gout typically happen in the foot. Podiatrists diagnose and treat diseases of the foot, ankle, and related leg structures. Dr. Scott Neville explains the early signs of gout and when it’s time to see a specialist.

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Hi, I'm Doctor Scott Neville, and I’m a board-certified podiatrist. I specialize in conditions that affect the feet and lower legs, including gout. Although gout can impact the entire body, it commonly starts as pain and inflammation in the foot due to buildup of uric acid crystals.

If you have more than 1 flare in the past 12 months or the presence of tophi while on oral gout medication, your gout may be out of control. Find a gout specialist near you by entering your ZIP code in the search bar of the specialist finder.

Find a specialist who understands the impact of gout and how to treat it.

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Gout specialists like rheumatologists have considerable experience diagnosing uncontrolled gout and are familiar with the latest gout treatments. Nephrologists recognize the important challenges to treating gout in patients with chronic kidney disease and provide nuanced support for both conditions.

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Use this doctor discussion guide during your visit

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If you have flares even while taking oral gout medicine, it is important to tell a doctor. A gout specialist is a doctor who has experience treating uncontrolled gout. Find a gout specialist who can help you decide if KRYSTEXXA is right for you.

Questions about
KRYSTEXXA? Ask a Gout Nurse Advocate

Partner with a specialist who understands the impact of gout on the entire body.

Call 1-833-4MY-GOUT

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USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

  • wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • dizziness, fainting, fast or weak heartbeat or feeling nervous
  • reddening of the face, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
  • have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

  • ever had any heart problems or high blood pressure.
  • are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).