Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Jen’s gout story. 
Gary’s gout story. 
Thomas’s gout story. 
Khash’s Patient Access Liaison (PAL) story. 
Brian’s story about his commitment to treatment. 
Jen’s IV treatment story. 
Logan’s CKD and gout story. 
Adam’s CKD and gout story. 
Knock Down Gout. Narrator:
KRYSTEXXA® (pegloticase) is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion. Please listen to the Important Safety Information in this video.
Jen:
The gout pain was severe. It is unlike anything else I'd ever experienced, and it's literally like a band is just wrapped around your entire foot and is just tightening and tightening and tightening, and it feels like it's bone crushing. This pain impacted my life because just moving around is intense pain and you can't do anything. When nothing was working, I was really thinking, "This is my life. We know what it is, and I've been given medication for it, and it's not working, so what else is there to do at that point?” I was terrified. I can't live like this. I was kind of like, "Okay, I'll go see a new doctor, and he's a gout specialist. That's great. Maybe he can tell me a little bit more." He did mention KRYSTEXXA. This is an infusion drug, and it's a big-time commitment.
Narrator:
When trying to manage chronic gout, a uric acid level of less than 6 milligrams per deciliter is considered the target range.
Jen:
When I started KRYSTEXXA, I was in the 10s, my uric acid level, and when I was on KRYSTEXXA, I was at 0. It went completely down to 0 for my entire KRYSTEXXA treatment, and then it slowly built back up to normal from there. For me, I was at my complete breaking point when I finally said yes to KRYSTEXXA, but I hope that people don't get there, because they don't need to get there. KRYSTEXXA had such a positive impact on my life. I want that for other people.
Narrator:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you
receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if
you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA
clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares,
allergic
reactions (including infusion reactions). See “What is the most important information I should know
about
KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019
(COVID-19),
and vomiting.
This is not a complete list of all possible side effects. Call your doctor for
medical
advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
Narrator:
KRYSTEXXA® (pegloticase) is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout.
Narrator:
Serious allergic reactions may happen in some patients who received KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion. Please listen to the Important Safety Information in this video.
Gary:
I've had chronic gout since I was 24 years old, and wasn't until recent, maybe about 3 or 4 years ago, that really took control of my life and I spiraled out of control. Every movement feels like there is somebody in there with a pitchfork and they're stabbing at the joint.
Gary:
So there are crystals that start to form around the affected joints, and it becomes stiff. Any movement causes tremendous pain. I mean, people are known to cry. I cried. Finding the right physician who understands gout is key. I went through a gamut of different physicians who did not understand. I went through a gamut of different medications. So it wasn't until I came across a rheumatologist that understood my problem, and he tells me, "There is a medication. It's going to& take a lot of commitment from you, but I think it's going to be helpful. It's called KRYSTEXXA."
Narrator:
When trying to manage chronic gout, a uric acid level of less than 6 milligrams per deciliter is considered the target range.
Gary:
KRYSTEXXA actually tackled the problem, which is the uric acid level; that's the key. And so I own my life now, and gout doesn't own me.
Narrator:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you
receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if
you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA
clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares,
allergic
reactions (including infusion reactions). See “What is the most important information I should know
about
KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019
(COVID-19),
and vomiting.
This is not a complete list of all possible side effects. Call your doctor for
medical
advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
Thomas voiceover: The song is entitled “One Last Dream.” And just because it's a renewal of the dream I began with. It's the only dream that I still wish to have.
Thomas: When I was younger, started to teach myself guitar, and started to get a little bit better at that and was pursuing becoming the famous singer songwriter, but that eventually faded out. And because of the gout, that fade out continued for about 45 years.
I had a spot on my toes that kept getting larger and it kept getting worse. And I finally did go in and see a professional about it and was informed that it was gout. That was in about 2014 and other signs were not readily apparent to me at that point.
Eventually other things began to get worse. And in 2019, the gout was just completely out of control and the left wrist and finger joints in particular seemed to be for me the most affected. They would turn bright red, they would swell. The pain was intense. If you were sleeping and an attack began I mean it would wake you up. It was just impossible to get any kind of relief whatsoever.
The attacks themselves would sometimes come and last for two or three weeks at a time, and then maybe it'd be good for a month or two. I was at the point of I tried to play guitar, if I moved my fingers over to play a chord, they stayed there. They literally would lock in place. You'd have to take your other hand and move.
What I was being told is everything that we can do for gout is being done. It was a dead end, that there was nothing further to be pursued, and I just felt there had to be something else out there. After the discovery on the internet of KRYSTEXXA, I voiced that possibility to my physician.
SLATE: After researching possible treatments, Thomas discovered KRYSTEXXA (pegloticase), an infused medicine used to treat uncontrolled gout.
Thomas and his doctor decided this would be the best option for him.
Thomas: Instead of treating the pain or treating the swelling, treating the symptoms, it was the only thing currently that would actually eliminate the gout, that it would dissolve the crystals.
The first is the tennis ball elbow and after the very first treatment, it turned from a more hardened mass to more of a sponge like mass. It actually had changed just in that short time. So right away we knew that something good was going to transpire from this.
The flares did occur because of the drug's ability to dissolve the crystals. That process will actually create a flare because the crystals are breaking down and they're moving. So, you can get some pain, you can get some swelling from that, but certainly not to the degree that you had previously. And it was just one of those things where all of a sudden you were aware that you weren't aware of it anymore. It was just simply no longer there.
I would say currently in every possible way, I feel better now than I probably did 40 years ago. My confidence is higher. My ability to proceed with my life the way I wish is now possible.
I am a person who has been given a remarkable opportunity. We all have dreams throughout life. To be able to play guitar is the epitome and culmination of a lifelong dream.
P-KRY-US-01018
Khash:
When I was a young adult, I started noticing some of the characteristics of what later on became gout. Well, as time progressed, I felt like my gout was becoming more and more out of control. I get a phone call from my doctor, and he calls me to discuss gout with me. And I'm like, "Great, I've been dealing with this 25-years-plus."
Khash:
... and said, “Listen, we have this drug to help combat your gout. Are you open to it?" I said, "Yes." He was like, "We'll have a patient access liaison get in contact with you to discuss it further with you."
Lindsey:
Once you have the pre-medications in your system, the nurse is going to mix the KRYSTEXXA into an IV fluids bag. She's going to hang that up above your chair, start an IV, and the medication is going to infuse over 2 hours.
Khash:
My Patient Access Liaison, Lindsey, really took the time to explain it all to me.
Lindsey:
But after you get this first dose of KRYSTEXXA, in 2 weeks or 2 days before the next dose of KRYSTEXXA, you're going to go to the lab, you're going to get your blood drawn, and they're going to measure your serum uric acid level. Okay?
Khash:
She went over that KRYSTEXXA was IV therapy. “Initially, while we're combating it in your body, if you see any tophi, if you see anything, know that it's like a glacier. If you notice tophi on your skin, underneath it is 10 years of buildup to lead to that point. Initially, as we're attacking that, it's going to cause more flareups, more inflammation.” I'm like, "That's fine," because I've been dealing with that all these years. But I know that it's because it's a response to us dealing with the problem and getting uric acid and gout and the tophi out of my body. I'm 100% for it.
Khash:
It's a big commitment on my time, but given the severity of it and dealing with what I've had to deal with for 25 years or so, that seems small in comparison. Tomorrow's going to be my first IV therapy, so I'm looking forward to that. And it makes me look forward to the next 30, 40 years without having to deal with the same issues.
Lindsey:
You're going to have a whole team of professional nurses there to be watching you and monitoring you to make sure that you're safe.
Khash:
Excellent.
Lindsey:
Okay?
Narrator:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you
receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if
you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic
reactions (including infusion reactions). See “What is the most important information I should know
about
KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019
(COVID-19),
and vomiting.
This is not a complete list of all possible side effects. Call your doctor for
medical
advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
BRIAN:
Once I completed the treatment cycle, everything went away. All my tophi had completely disappeared.
BRIAN:
Living with uncontrolled gout, it's a challenge. I had this growth. It was the size of a golf ball. My kids, they would call it my sixth toe. You know you gotta kind of hobble and take it easy, take your time. Just to get up to go to the bathroom, it just makes you just a different person.
BRIAN:
The two main things that you'll go through is, you got to have the time commitment. You got to be able to be flexible with your time, so you may have to take time off of work. I’m glad I did it.
BRIAN:
You may have a few gout flares at the beginning, but those may be your last. One of the nurses at the infusion center, she's like, "It's a challenge right now, and you are going through some changes, but be patient and stick with it."
BRIAN:
You've got a big support system. Your Patient Access Liaison is your pal because they do help you to get through this trying time, and you also have mentors who have actually gone through the program. It makes a big difference talking to somebody that's gone through it.
BRIAN:
Imagine where you've been, what you've gone through already, how much this has affected your life. Six months to a year, maybe a little bit longer, it was worth it.
BRIAN:
I've got kids in Ohio, Florida, here. Nowadays, I can hop on a plane and go visit them. I’m glad I stuck with it.
NARRATOR:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you
receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if
you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA
clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares,
allergic
reactions (including infusion reactions). See “What is the most important information I should know
about
KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019
(COVID-19),
and vomiting.
This is not a complete list of all possible side effects. Call your doctor for
medical
advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
Narrator:
KRYSTEXXA® (pegloticase) is a prescription medicine for adults who have tried other gout medicines and still have high uric acid and gout symptoms. KRYSTEXXA is not recommended if you have high levels of uric acid without a history of gout. Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion. Please listen to the Important Safety Information in this video.
Jennifer:
I first got gout about 3 or 4 years ago, and it just got worse and worse and worse. It got to the point where I was getting gout every 3 weeks before I made it to a rheumatologist. Gout flares are intense, just bone-crushing pain. I was basically at my wits’ end. None of the medications that I was using were working for me.
Jennifer:
My doctor told me about KRYSTEXXA, or pegloticase. He explained that KRYSTEXXA would work differently from the other medications that I was on. It was an infusion treatment that he thought could help my gout flares. And at the very end of my appointment, he walked me back to the infusion room to see this is not a huge, scary place, that it would go in and could get rid of all the uric acid buildup I had over the years.
Dr Christopher Parker:
Uric acid is not an abnormal thing in somebody's body. Everybody has uric acid. But in some people, we have a hard time getting rid of it all out of our body and it can just build up. KRYSTEXXA is an enzyme that's going to break that down, and quickly. Within a matter of a day, their uric acid level will come down, and every time they get their infusion, I am checking that uric acid level and I'm wanting to see that that uric acid level is always in what I call the sweet spot, really less than 6.
Jennifer:
My doctor warned me that starting KRYSTEXXA might cause gout flares because it takes your uric acid from a high number, 9 or 10, typically down to 0 overnight, or within 6 hours of treatment. So you can experience a gout flare from that drastic change in uric acid. He also warned me that you could get an allergic reaction during treatment. So I went into it a little bit nervous, honestly.
Jennifer:
When I first arrived, they bring you back to the infusion room. A nurse brings you back. And then they get you set up in the chair.
Jasmine Kershaw:
Most of the time, if it's the first infusion, they're nervous. So we will sit down in the infusion room and even though the doctor has explained what the medication is and what it treats, we still go over that again, just to reassure the patient.
Jasmine Kershaw:
We also go over how long or how often they will need to come. The typical infusion is every 2 weeks, and it can vary between 6 to 8 months for the length of time.
Jennifer:
When you think about 6 months compared to how long you had had gout before, that is what you have to do to get through it.
Dr Christopher Parker:
KRYSTEXXA definitely is a tool in my toolbox for patients that need it that I wouldn't want to be without. The most rewarding part of my job is the patient stories. For sure.
Jennifer:
KRYSTEXXA really made a difference for me. It brought my uric acid levels down to normal, and I'm able to do things that I love doing, like getting my life back pretty much.
Narrator:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if
you:
What should I tell my doctor before receiving treatment with
KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical
conditions,
including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical
trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic
reactions
(including infusion reactions). See “What is the most important information I should know about
KRYSTEXXA?”,
nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and
vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical
advice
about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
USE
KRYSTEXXA® (pegloticase) is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
LOGAN: I’ve learned that I’m a lot stronger than I thought I would be.
LOGAN: Growing up was a lot of outdoors, a lot of sports with my siblings and it was a lot of camaraderie, it was great. When I was around 8 to 10 was really when I started to see some significant differences. Getting tired really easy was kind of a vague first one as a young child just to start to realize maybe I can’t keep up with everybody else. Another part of it was joint pain, inflammation, and that’s really what kind of ticked off and started everything.
It’s hard to understand when you’re so young, but having my mother that kind of experienced the same thing led the professionals to believe that maybe it was something genetic.
I did receive a diagnosis of renal insufficiency. So, there was things that they would diagnose me with, and maybe misdiagnose, because they didn’t think that a young kid could get gout or renal failure to that degree.
I was probably 16 when I first had experience with uncontrolled gout, and it was severe.
It went from zero to 100 extremely fast, extremely rapidly. My hands, my joints would ache. You cannot put your own socks and shoes on. You can’t get out of bed. You can’t walk. In those adolescent years, it was something that was very difficult for me. I wouldn’t wish it on anyone.
The medicine that I was prescribed as a young adult did not give me the relief that was necessary to keep me active, keep me on my feet, and keep me going. Although I was living with my chronic kidney disease, I knew I had to still take care of my uncontrolled gout.
I think when my nephrologist finally told me that I had uncontrolled gout, it was something that I had to sit down and really understand. At that time, they didn’t see any kids that had the same situation. And so, I was living with gout for about eight years before I found KRYSTEXXA.
KRYSTEXXA was something that maybe I was nervous about, but I was also excited because I’m willing to try. My nephrologist explained it to me as “KRYSTEXXA is an infusable drug that you take once every couple of weeks, and it really helps break down the uric acid in your joints, in your bones.”
It was kind of scary at first but I have a patient access liaison named Karen, and she is phenomenal. She really helped me with making sure I was organized with my appointments, making sure that I was where I needed to be and was truly taken care of behind the scenes. It really felt like I had someone on my team.
It’s huge. Every treatment that I had, I would feel better. I can be a lot more active. I can put on my own socks and shoes.
One of the biggest things is that joint pain, that inflammation, the tophi that comes through your skin has all diminished since starting KRYSTEXXA. I think with my mother, with my fiancée, the support has been astronomical. It’s been incredible.
I was able to join my fiancée in hikes and fishing, and golfing was a huge thing that I missed for a very long time. KRYSTEXXA has really given me the opportunity to keep going and keep putting one foot in front of the other every day.
I mean, truly incredible. So, if you have the opportunity, take it.
ADAM:
Back in 2015, I started waking up stiff. Like, hard to get out bed and getting up and walking was extreme pain. Getting out of a bed of a morning was a chore like getting socks on was almost impossible. My fingers was the size of grapes, my elbows the size of grapefruits, literally the size of grapefruits. And like, playing guitar is something I like to do on a regular basis. And it got to where I couldn’t play guitar.
It was like rocks and like, it impacted my whole life. I couldn’t do anything. I was going to the hospital on a regular basis getting steroid shots. I went to multiple rheumatologists. I never really got no clear answer from multiple doctors.
It’s so impacting on not only yourself psychologically, but your family, because your family wants you go do stuff with them and you can’t. And the pain is excruciating, like getting up, walking without some kind of support on your feet. It feels like you’re walking through hot coals of fire. It basically shuts your life down.
Living with chronic kidney disease or CKD is a progressive thing.
I found the one rheumatologist. And she’s like, she looked at me. She’s like, “I know your problem.” It was like, a light bulb kicked on. I was like, “Can we fix this?” And she said, “Absolutely.”
She gave me hope. And you know especially when you can see the light at the end of the tunnel, you know, that’s what I was looking at – focusing on that focal point was the end of the tunnel.
She explained the process to me every two weeks. She told me the risk but I was willing to do anything at that time. And she told me, you know what to expect. The gout flares that I would have from the medication. After about two months I started to have really, really bad gout flares. But after that, it subsided.
I started experiencing changes. I could go out and walk a half a mile. You know, I couldn’t do this stuff in years. I started—picked my guitar up. That was one of my favorite pastimes in life was my guitar. And I literally could see, you know, the tophi like disappearing.
I could get down on the floor, I could get back up. You know, I could get out of bed, go get a shower, no assistance, you know, just going in and cooking a simple dinner was easy after that.
I watch my lab work and like my uric acid levels drop, my uric acid levels were running like 12-13 up close 14, you know, dropped down to like point five or undetectable.
I really never thought this would ever be possible. You know, going from a life of pretty much being in bed, immobile to out to where I do everything I do today. Like, me and my son get to do stuff on a daily basis. Fly fishing’s one of my favorite things like it would have been impossible to bait a hook, tie flies. I’m out there in a river. I’m in waders. I can fly fish, I can tie my own flies. I can do all that. And it just wasn’t possible before.
I try not to reflect back on my past. I focus on the future and how I can help other people. Don’t accept anything you think’s wrong or you don’t think is right. You know, you seek that, you find that answer. And that’s what I’ve done.
Gregory:The swollen lumps I had from gout interfered with my life. My doctor diagnosed me with uncontrolled gout since I was taking gout pills but still had a high uric acid level, gouty lumps, and more than one flare a year. She prescribed KRYSTEXXA. Unlike pills, KRYSTEXXA is an infused medicine that starts reducing uric acid within 24 hours. Studies have shown that most of the buildup of uric acid crystals on the bones and joints can be dissolved in 6 to 12 months.
Legal VO: KRYSTEXXA is an infused prescription medicine for adults with gout not controlled by other gout treatments. Serious life-threatening allergic reactions can occur. Tell your doctor right away if you
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if you:
What should I tell my doctor before receiving treatment with KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical trials:
The most common side effects of
KRYSTEXXA
when given together with methotrexate were gout flares, joint pain,
coronavirus disease 2019
(COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA
were gout
flares, allergic reactions (including infusion reactions). See “What is the most
important information I
should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain,
coronavirus disease
2019 (COVID-19), and vomiting.
This is not a complete list of all possible side
effects. Call your
doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.