Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
Attend a virtual event with a gout specialist on 3/19, 4/23, and 5/14
It can take years for uric acid crystals to build up and cause a gout attack. That’s why many people with uncontrolled chronic gout are diagnosed by gout specialists later in life. If your oral gout medicine isn’t doing enough to lower your uric acid level, over time your gout symptoms may become harder and harder to manage.
If you take oral gout medicine and still have a persistently high uric acid level above 6 mg/dL, you may experience:
Frequent gout flares (more than 1 flare a year)
Increased risk of future flares
Visible lumps called tophi under your skin
Severe gout pain
Flares in more areas of your body
Pain or stiffness in your joints
Joint and bone damage
If you have flares despite taking oral gout medicine, it’s important to talk
with a specialist who can design a treatment plan that works for you.
Some medicines relieve the symptoms of a gout attack. Other medicines target uric acid to prevent attacks from happening in the first place. If your kidneys are not working as well as they should, your doctor has to be careful about which medicines are prescribed. This is one reason why taking control of gout can be challenging when you have kidney disease and gout.KRYSTEXXA is an effective treatment with an established safety profile.
Medicines that relieve gout symptoms include:
Medicines that limit uric acid production include:
The only medicine that converts uric acid into a substance your body easily gets rid of and that can start lowering your uric acid level within 24 hours of your first treatment:
Take a short quiz to see if you have uncontrolled gout.
See how real patients took back control of gout with KRYSTEXXA.
What is the most important information I should know about KRYSTEXXA® (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.
KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.
Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
Who should not receive KRYSTEXXA?
Do not receive KRYSTEXXA if you:
What should I tell my doctor before receiving treatment with KRYSTEXXA?
Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.
KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.
What are the possible side effects of KRYSTEXXA?
In KRYSTEXXA clinical trials:
The most common side effects of
KRYSTEXXA
when given together with methotrexate were gout flares, joint pain,
coronavirus disease 2019
(COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA
were gout
flares, allergic reactions (including infusion reactions). See “What is the most
important information I
should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain,
coronavirus disease
2019 (COVID-19), and vomiting.
This is not a complete list of all possible side
effects. Call your
doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.
KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).
What is the most important information I should know about KRYSTEXXA?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.