Gout and Kidney Disease | KRYSTEXXA® (pegloticase)

Kidney Disease and Gout

Learn about the important link between kidney disease and gout and have a discussion with your doctor

Logan experienced chronic kidney disease (CKD) and gout

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With the help of his PAL, Logan managed to stay on track with his treatment for uncontrolled gout.

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LOGAN: I’ve learned that I’m a lot stronger than I thought I would be.

LOGAN: Growing up was a lot of outdoors, a lot of sports with my siblings and it was a lot of camaraderie, it was great. When I was around 8 to 10 was really when I started to see some significant differences. Getting tired really easy was kind of a vague first one as a young child just to start to realize maybe I can’t keep up with everybody else. Another part of it was joint pain, inflammation, and that’s really what kind of ticked off and started everything.

It’s hard to understand when you’re so young, but having my mother that kind of experienced the same thing led the professionals to believe that maybe it was something genetic.

I did receive a diagnosis of renal insufficiency. So, there was things that they would diagnose me with, and maybe misdiagnose, because they didn’t think that a young kid could get gout or renal failure to that degree.

I was probably 16 when I first had experience with uncontrolled gout, and it was severe.

It went from zero to 100 extremely fast, extremely rapidly. My hands, my joints would ache. You cannot put your own socks and shoes on. You can’t get out of bed. You can’t walk. In those adolescent years, it was something that was very difficult for me. I wouldn’t wish it on anyone.

The medicine that I was prescribed as a young adult did not give me the relief that was necessary to keep me active, keep me on my feet, and keep me going. Although I was living with my chronic kidney disease, I knew I had to still take care of my uncontrolled gout.

I think when my nephrologist finally told me that I had uncontrolled gout, it was something that I had to sit down and really understand. At that time, they didn’t see any kids that had the same situation. And so, I was living with gout for about eight years before I found KRYSTEXXA.

KRYSTEXXA was something that maybe I was nervous about, but I was also excited because I’m willing to try. My nephrologist explained it to me as “KRYSTEXXA is an infusable drug that you take once every couple of weeks, and it really helps break down the uric acid in your joints, in your bones.”

It was kind of scary at first but I have a patient access liaison named Karen, and she is phenomenal. She really helped me with making sure I was organized with my appointments, making sure that I was where I needed to be and was truly taken care of behind the scenes. It really felt like I had someone on my team.

It’s huge. Every treatment that I had, I would feel better. I can be a lot more active. I can put on my own socks and shoes.

One of the biggest things is that joint pain, that inflammation, the tophi that comes through your skin has all diminished since starting KRYSTEXXA. I think with my mother, with my fiancée, the support has been astronomical. It’s been incredible.

I was able to join my fiancée in hikes and fishing, and golfing was a huge thing that I missed for a very long time. KRYSTEXXA has really given me the opportunity to keep going and keep putting one foot in front of the other every day.

I mean, truly incredible. So, if you have the opportunity, take it.

Is chronic kidney disease connected to gout?

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA® (pegloticase)?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:

wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
dizziness, fainting, fast or weak heartbeat or feeling nervous
reddening of the face, itching, hives, or feeling warm
swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. Your doctor may test you for G6PD before you start KRYSTEXXA.
have had a serious allergic reaction to KRYSTEXXA or any of its ingredients. See the end of the Medication Guide for a complete list of ingredients in KRYSTEXXA.

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

ever had any heart problems or high blood pressure.
are pregnant or plan to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric), or probenecid, while receiving KRYSTEXXA.

KRYSTEXXA is recommended to be given with another prescription medicine called methotrexate. KRYSTEXXA may also be used alone. You and your doctor will decide the treatment that is right for you.

Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your risk of getting gout flares or an allergic reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.

Your gout flares may increase in the first 3 months when you start receiving KRYSTEXXA. It’s important to understand that this is happening because KRYSTEXXA is breaking down uric acid in your body. Do not stop receiving KRYSTEXXA even if you have a flare, as the amount of flares will decrease after 3 months of treatment. Your doctor may give you other medicines to help reduce your gout flares for the first few months after starting KRYSTEXXA.

What are the possible side effects of KRYSTEXXA?

In KRYSTEXXA clinical trials:
The most common side effects of KRYSTEXXA when given together with methotrexate were gout flares, joint pain, coronavirus disease 2019 (COVID-19), nausea, and fatigue.
The most common side effects of KRYSTEXXA were gout flares, allergic reactions (including infusion reactions). See “What is the most important information I should know about KRYSTEXXA?”, nausea, bruising, sore throat, constipation, chest pain, coronavirus disease 2019 (COVID-19), and vomiting.
This is not a complete list of all possible side effects. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

For additional Important Safety Information, please see the Medication Guide and discuss with your doctor.

USE

KRYSTEXXA is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.

KRYSTEXXA is not for use in people with too much uric acid in their bodies who do not have symptoms (asymptomatic hyperuricemia).

USE AND IMPORTANT SAFETY INFORMATION

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life-threatening and usually happen within 2 hours of the infusion.

Kidney Disease and Gout

Learn about the important link between kidney disease and gout and have a discussion with your doctor

This information is intended for

US Healthcare Professionals

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Logan experienced chronic kidney disease (CKD) and gout

Is chronic kidney disease connected to gout?

Is gout medicine bad for your kidneys?

Do what you can to help yourself

Uncontrolled chronic gout is serious

USE AND IMPORTANT SAFETY INFORMATION

USE

USE AND IMPORTANT SAFETY INFORMATION